P289 Intestinal obstruction syndromes in cystic fibrosis

Meconium ileus (MI) presents at birth as small bowel obstruction. Distal Intestinal Obstruction Syndrome (DIOS) is a faecal obstruction of the ileocaecum after neonatal period. We undertook retrospective review all patients our CF Centre to characterise spectrum intestinal syndromes. 404 patients, 36(9%) had presented with MI. All pancreatic insufficiency; 21(58%) were male; 26(72%) required surgery, 10(28%) resolved gastrografin enemas; 17(47%) developed DIOS over their subsequent life course; 19(53%) no mean 28.5(19–57) years. 63 (16%) –42 male (67%)-developed 118 episodes DIOS, requiring hospital admission; 39 single episode, 24 recurrent (2–12) episodes. 35(56%) F508del/F508del, 26(41%) F508del/other; 6 post-lung transplant. Gastrografin was used treat 109 episodes, via nasogastric tube in 77, gastrostomy and orally 26, laxatives 2 colonoscopies terminal ileum; parenteral nutrition during prolonged DIOS; 7 surgery for unresolved or complications. Other causes adhesions 12(3%), intussusception 5(1.2%), volvulus 2(0.5%). There 3 (0.75%) cases fibrosing colonopathy childhood, 3(0.75%), cancers C.difficile colitis 3(0.75%). acute abdominal pain cholecystitis 33(8%), renal calculi 27(7%), appendicitis 18(4.5%), pancreatitis 16(4%) ovarian conditions 8(2%). an unpredictable emergency, which must be distinguished from colonic constipation other problems. Medical management by team usually successful, but surgical radiology advice are important detect complications Supported Trust; Grant No. VIA 099.